A lively account of how Darwin’s work on natural selection transformed science and society, and an investigation into the mysterious illness that plagued its author.By early morning of June 30, 1860, a large crowd began to congregate in front of Oxford University’s brand-new Museum of Natural History. The occasion was the annual meeting of the British Association for the Advancement of Science, and the subject of discussion was Charles Darwin’s new treatise: fact or fiction?Darwin, a simultaneously reclusive and intellectually audacious squire from Kent, claimed to have solved “that mystery of mysteries,” introducing a logical explanation of the origin of species―how they adapted, even transmogrified, through natural selection. At stake, on that summer’s day of spirited debate, was the very foundation of modern biology, not to mention the future of the church. Without fear of exaggeration, Darwin’s thesis would forever change our understanding of the life sciences and the natural world. And yet the author himself was nowhere to be found in the debate hall―instead, he was miles away, seeking respite from a spate of illnesses that had plagued him for much of his adult life.In Origin Story, medical historian Howard Markel recounts the two-year period (1858 to 1860) of Darwin’s writing of On the Origin of Species through its spectacular success and controversy. Simultaneously, Markel delves into the mysterious health symptoms Darwin developed, combing the literature to emerge with a cogent diagnosis of a case that has long fascinated medical historians. The result is a colorful portrait of the man, his friends and enemies, and his seminal work, which resonates to this day. 83 illustrations

This book is a go-to guide for all families seeking trustworthy information about the science and safety of vaccines. Paul A. Offit and Charlotte A. Moser―scientists and parents with decades of experience―equip readers with the facts they need to navigate vaccine decisions for the whole family, from babies to elders. In straightforward prose, they offer accessible and authoritative answers to today’s most common vaccine-related questions.Offit and Moser explain how vaccines work, how they are made, and how they are tested. Chapters examine vaccine safety, ingredients, the workings of the immune system, and practical considerations from the implications of different medical conditions to missed doses. The book covers vaccines that have been available for decades as well as newer vaccines for illnesses such as RSV, COVID-19, and mpox, including both traditional and mRNA vaccines. The second half of the book is a guide to individual vaccines organized by age groups, including the first and second year of life, ages three to six, older children and teenagers, and adults. A timely resource for all families, this book allays unfounded fears and provides a clear, easy-to-understand picture of vaccines and vaccination.Vaccines and Your Family is a revised and updated edition of Vaccines and Your Child (2011) that expands coverage to include all ages and addresses recent scientific progress. It explores the new recommendations and new questions regarding vaccines that have arisen in the intervening years.

A smart and compelling examination of the science of immunity, the public policy implications of vaccine denial, and the real-world outcomes of failing to vaccinate. If you have a child in school, you may have heard stories of long-dormant diseases suddenly reappearing―cases of measles, mumps, rubella, and whooping cough cropping up everywhere from elementary schools to Ivy League universities because a select group of parents refuse to vaccinate their children.Between Hope and Fear tells the remarkable story of vaccine-preventable infectious diseases and their social and political implications. While detailing the history of vaccine invention, Kinch reveals the ominous reality that our victories against vaccine-preventable diseases are not permanent―and could easily be undone. In the tradition of John Barry’s The Great Influenza and Siddhartha Mukherjee’s The Emperor of All Maladies, Between Hope and Fear relates the remarkable intersection of science, technology and disease that has helped eradicate many of the deadliest plagues known to man. 8 pages of color photographs

With employers offering free flu shots and pharmacies expanding into one-stop shops to prevent everything from shingles to tetanus, vaccines are ubiquitous in contemporary life. The past fifty years have witnessed an enormous upsurge in vaccines and immunization in the United States: American children now receive more vaccines than any previous generation, and laws requiring their immunization against a litany of diseases are standard. Yet, while vaccination rates have soared and cases of preventable infections have plummeted, an increasingly vocal cross section of Americans have questioned the safety and necessity of vaccines. In Vaccine Nation, Elena Conis explores this complicated history and its consequences for personal and public health.Vaccine Nation opens in the 1960s, when government scientists―triumphant following successes combating polio and smallpox―considered how the country might deploy new vaccines against what they called the “milder” diseases, including measles, mumps, and rubella. In the years that followed, Conis reveals, vaccines fundamentally changed how medical professionals, policy administrators, and ordinary Americans came to perceive the diseases they were designed to prevent. She brings this history up to the present with an insightful look at the past decade’s controversy over the implementation of the Gardasil vaccine for HPV, which sparked extensive debate because of its focus on adolescent girls and young women. Through this and other examples, Conis demonstrates how the acceptance of vaccines and vaccination policies has been as contingent on political and social concerns as on scientific findings.By setting the complex story of American vaccination within the country’s broader history, Vaccine Nation goes beyond the simple story of the triumph of science over disease and provides a new and perceptive account of the role of politics and social forces in medicine.

From one of the world’s top virologists, the definitive guide to understanding—and navigating—COVID-19.Three years on, COVID is clearly here to stay. So what do we do now? Drawing on his expertise as one of the world’s top virologists, Dr. Paul Offit helps weary readers address that crucial question in this brief, definitive guide.As a member of the FDA Vaccine Advisory Committee and a former member of the Advisory Committee for Immunization Practices to the CDC, Offit has been in the room for the creation of policies that have affected hundreds of millions of people.In these pages, he marshals the power of hindsight to offer a fascinating frontline look at where we were, where we are, and where we’re heading in the now-permanent fight against the disease.Accompanied by a companion website populated with breaking news and relevant commentary, this book contains everything you need to know to navigate COVID going forward. Offit addresses fundamental issues like boosters, immunity induced by natural infection, and what it means to be fully vaccinated. He explores the dueling origin stories of the disease, tracing today’s strident anti-vax rhetoric to twelve online sources and tracking the fallout. He breaks down long COVID—what it is, and what the known treatments are. And he looks to the future, revealing whether we can make a better vaccine, whether it should be mandated, and providing a crucial list of fourteen takeaways to eradicate further spread.Filled with pragmatic analysis and sensible advice, TELL ME WHEN IT’S OVER is for anyone interested in finding new solutions to the new normal.

One of America’s top physicians traces the history of risk in medicine—with powerful lessons for todayEvery medical decision—whether to have chemotherapy, an X-ray, or surgery—is a risk, no matter which way you choose. In You Bet Your Life, physician Paul A. Offit argues that, from the first blood transfusions four hundred years ago to the hunt for a COVID-19 vaccine, risk has been essential to the discovery of new treatments. More importantly, understanding the risks is crucial to whether, as a society or as individuals, we accept them.Told in Offit’s vigorous and rigorous style, You Bet Your Life is an entertaining history of medicine. But it also lays bare the tortured relationships between intellectual breakthroughs, political realities, and human foibles. Our pandemic year has shown us, with its debates over lockdowns, masks, and vaccines, how easy it is to get everything wrong. You Bet Your Life is an essential read for getting the future a bit more right.

Dr. Peter Hotez discusses how the antivaccine movement became a dangerous political campaign promoted by elected officials and amplified by news media, causing thousands of American deaths.Shortlisted for the Non-Obvious Book Awards by the Non-Obvious CompanyDuring the height of the COVID-19 pandemic, one renowned scientist, in his famous bowtie, appeared daily on major news networks such as MSNBC, NPR, the BBC, and others. Dr. Peter J. Hotez often went without sleep, working around the clock to develop a nonprofit COVID-19 vaccine and to keep the public informed. During that time, he was one of the most trusted voices on the pandemic and was even nominated for a Nobel Peace Prize for his selfless work. He also became one of the main targets of anti-science rhetoric that gained traction through conservative news media.In this eyewitness story of how the anti-vaccine movement grew into a dangerous and prominent anti-science element in American politics, Hotez describes the devastating impacts it has had on Americans' health and lives. As a scientist who has endured antagonism from anti-vaxxers and been at the forefront of both essential scientific discovery and advocacy, Hotez is uniquely qualified to tell this story. By weaving his personal experiences together with information on how the anti-vaccine movement became a tool of far-right political figures around the world, Hotez opens readers' eyes to the dangers of anti-science. He explains how anti-science became a major societal and lethal force: in the first years of the pandemic, more than 200,000 unvaccinated Americans needlessly died despite the widespread availability of COVID-19 vaccines. Even as he paints a picture of the world under a shadow of aggressive ignorance, Hotez demonstrates his innate optimism, offering solutions for how to combat science denial and save lives in the process.

Science doesn’t speak for itself. Neck-deep in work that can be messy and confounding and naïve in the ways of public communication, scientists are often unable to package their insights into the neat narratives that the public requires. Enter celebrities, advocates, lobbyists, and the funders behind them, who take advantage of scientists’ reluctance to provide easy answers, flooding the media with misleading or incorrect claims about health risks. Amid this onslaught of spurious information, Americans are more confused than ever about what’s good for them and what isn’t.In Bad Advice, Paul A. Offit shares hard-earned wisdom on the dos and don’ts of battling misinformation. For the past twenty years, Offit has been on the front lines in the fight for sound science and public heath. Stepping into the media spotlight as few scientists have done―such as being one of the first to speak out against conspiracy theories linking vaccines to autism―he found himself in the crosshairs of powerful groups intent on promoting pseudoscience. Bad Advice discusses science and its adversaries: not just the manias stoked by slick charlatans and their miracle cures but also corrosive, dangerous ideologies such as Holocaust and climate-change denial. Written with wit and passion, Offit’s often humorous guide to taking on quack experts and self-appointed activists is a must-read for any American disturbed by the uptick in politicized attacks on science.

What happens when ideas presented as science lead us in the wrong direction?History is filled with brilliant ideas that gave rise to disaster, and this book explores the most fascinating—and significant—missteps: from opium's heyday as the pain reliever of choice to recognition of opioids as a major cause of death in the U.S.; from the rise of trans fats as the golden ingredient for tastier, cheaper food to the heart disease epidemic that followed; and from the cries to ban DDT for the sake of the environment to an epidemic-level rise in world malaria.These are today's sins of science—as deplorable as mistaken past ideas about advocating racial purity or using lobotomies as a cure for mental illness. These unwitting errors add up to seven lessons both cautionary and profound, narrated by renowned author and speaker Paul A. Offit. Offit uses these lessons to investigate how we can separate good science from bad, using some of today's most controversial creations—e-cigarettes, GMOs, drug treatments for ADHD—as case studies. For every "Aha!" moment that should have been an "Oh no," this book is an engrossing account of how science has been misused disastrously—and how we can learn to use its power for good.

In recent years, there have been major outbreaks of whooping cough among children in California, mumps in New York, and measles in Ohio's Amish country -- despite the fact that these are all vaccine-preventable diseases. Although America is the most medically advanced place in the world, many people disregard modern medicine in favor of using their faith to fight life threatening illnesses. Christian Scientists pray for healing instead of going to the doctor, Jehovah's Witnesses refuse blood transfusions, and ultra-Orthodox Jewish mohels spread herpes by using a primitive ritual to clean the wound. Tragically, children suffer and die every year from treatable diseases, and in most states it is legal for parents to deny their children care for religious reasons. In twenty-first century America, how could this be happening?In Bad Faith, acclaimed physician and author Dr. Paul Offit gives readers a never-before-seen look into the minds of those who choose to medically martyr themselves, or their children, in the name of religion. Offit chronicles the stories of these faithful and their children, whose devastating experiences highlight the tangled relationship between religion and medicine in America. Religious or not, this issue reaches everyone -- whether you are seeking treatment at a Catholic hospital or trying to keep your kids safe from diseases spread by their unvaccinated peers.Replete with vivid storytelling and complex, compelling characters, Bad Faith makes a strenuous case that denying medicine to children in the name of religion isn't't just unwise and immoral, but a rejection of the very best aspects of what belief itself has to offer.

In Do You Believe in Magic?, medical expert Paul A. Offit, M.D., offers a scathing exposé of the alternative medicine industry, revealing how even though some popular therapies are remarkably helpful due to the placebo response, many of them are ineffective, expensive, and even deadly.Dr. Offit reveals how alternative medicine—an unregulated industry under no legal obligation to prove its claims or admit its risks—can actually be harmful to our health.Using dramatic real-life stories, Offit separates the sense from the nonsense, showing why any therapy—alternative or traditional—should be scrutinized. He also shows how some nontraditional methods can do a great deal of good, in some cases exceeding therapies offered by conventional practitioners.An outspoken advocate for science-based health advocacy who is not afraid to take on media celebrities who promote alternative practices, Dr. Offit advises, “There’s no such thing as alternative medicine. There’s only medicine that works and medicine that doesn’t.”

In 2010, California suffered the largest and deadliest outbreak of pertussis, also known as “whooping cough,€ in more than fifty years. This tragedy was avoidable. An effective vaccine has been available since the 1940s. In recent years other diseases, like measles and mumps, have also made a comeback. The reason for these epidemics can be traced to a group whose vocal proponents insist, despite evidence to the contrary, that vaccines are poison. As a consequence, parents and caretakers are rejecting vaccines for themselves and their families.In Deadly Choices, infectious-disease expert Paul Offit takes a look behind the curtain of the anti-vaccine movement. What he finds is a reminder of the power of scientific knowledge, and the harm we risk if we ignore it.

Vaccines save millions of lives every year, and one man, Maurice Hilleman, was responsible for nine of the big fourteen. Paul Offit recounts his story and the story of vaccinesMaurice Hilleman discovered nine vaccines that practically every child gets, rendering formerly dread diseases—including often devastating ones such as mumps and rubella—practically forgotten. Paul A. Offit, a vaccine researcher himself, befriended Hilleman and, during the great man’s last months, interviewed him extensively about his life and career.Offit makes an eloquent and compelling case for Hilleman’s importance, arguing that, like Jonas Salk, his name should be known to everyone. But Vaccinated is also enriched and enlivened by a look at vaccines in the context of modern medical science and history, ranging across the globe and throughout time to take in a fascinating cast of hundreds, providing a vital contribution to the continuing debate over the value of vaccines.

Vaccines have saved more lives than any other single medical advance. Yet today only four companies make vaccines, and there is a growing crisis in vaccine availability. Why has this happened? This remarkable book recounts for the first time a devastating episode in 1955 at Cutter Laboratories in Berkeley, California, thathas led many pharmaceutical companies to abandon vaccine manufacture.Drawing on interviews with public health officials, pharmaceutical company executives, attorneys, Cutter employees, and victims of the vaccine, as well as on previously unavailable archives, Dr. Paul Offit offers a full account of the Cutter disaster. He describes the nation’s relief when the polio vaccine was developed by Jonas Salk in 1955, the production of the vaccine at industrial facilities such as the one operated by Cutter, and the tragedy that occurred when 200,000 people were inadvertently injected with live virulent polio virus: 70,000 became ill, 200 were permanently paralyzed, and 10 died. Dr. Offit also explores how, as a consequence of the tragedy, one jury’s verdict set in motion events that eventually suppressed the production of vaccines already licensed and deterred the development of new vaccines that hold the promise of preventing other fatal diseases.

Immunization is regarded by many as one of the greatest advances in modern civilization. The widespread use of vaccines has led to increases in life expectancy, reductions in the occurrence of childhood diseases, and is generally credited with saving millions of lives annually.But since their discovery two centuries ago, vaccines have been dogged by pockets of persistent distrust among those who are skeptical of their science or who find compulsory immunization at odds with personal liberty. The rise of these voices in contemporary culture has contributed to trends of vaccine delay and vaccine hesitancy in some communities -- a chasm between the general population and the scientific establishment that has persisted and grown at times across the last several decades.Vaccines: What Everyone Needs to Know® offers a scientifically grounded overview of the science, manufacture, and culture of vaccines in the United States and internationally. Aiming to offer an unbiased resource on this hotly debated subject, it provides accessible, authoritative overviews of the following:· How vaccines work· The history of vaccines· Vaccine policy -- who writes it, and does it matter?· The contents and manufacture of vaccines· Vaccine injury· The alleged link between vaccines and autism· Vaccines and new outbreaksWritten by a leading authority in both infectious disease and vaccine education, this book offers a clear-eyed resource for parents or anyone with an interest in the use, efficacy, and controversy surrounding vaccines. In a subject area defined by partisanship, it offers reliable resource for what everyone needs to know.

Congratulations! You’re pregnant! Now, where do you turn to for the best advice? What if you could bottle the wisdom of all those women who came before you—and combine it with the solid medical advice from a renowned Beverly Hills’ OB/GYN and nationally known pediatrician? Expecting 411 is the answer: smart, up-to-date and refreshingly free of paranoia, this is the book you’ll turn to for quick answers to your most pressing questions. Inside, you'll find:Is this normal? From morning sickness to stretch marks, you’ll learn what’s expected—and what’s not.Is it safe? Sushi? Hair dye? Coffee? Get detailed do’s and don’ts.How much weight should I gain? Find the latest guidelines.Breastfeeding 101. Learn the secrets of nursing from an expert.Detailed advice on prepping for parenthood, including all the decisions you need to make. What tests are required? Are optional?Easy-to-find answers on natural childbirth, nutrition, epidurals, when to call the doc and more!The new, revised and updated 2nd edition includes even more great advice:New research on how to prevent preterm births.Fish facts and fish tales. What's safe, what's not, and why you SHOULD eat fish.The latest warnings on medications during pregnancy.Expanded tips and advice on exercise.Protecting your newborn from whooping cough and flu.All that and more in the revised and updated Expecting 411, 2nd editon.

A father's inspiring portrait of his daughter informs this classic reassessment of the "epidemic" of autism.When Isabel Grinker was diagnosed with autism in 1994, it occurred in only about 3 of every 10,000 children. Within ten years, rates had skyrocketed. Some scientists reported rates as high as 1 in 150. The media had declared autism an epidemic.Unstrange Minds documents the global quest of Isabel's father, renowned anthropologist Roy Richard Grinker, to discover the surprising truth about why autism is so much more common today. In fact, there is no autism epidemic. Rather, we are experiencing an increase in autism diagnoses, and Grinker shows that the identification and treatment of autism depends on culture just as much as it does on science.Filled with moving stories and informed by the latest science, Unstrange Minds is a powerful testament to a father's search for the truth.

Do Vaccines Cause Autism, Asthma, Diabetes? Get straight, science-based answers to this and other questions about the safety of vaccines. In this book you will find the facts--no advocating hype or anti-vaccine propaganda. You will discover how to: * Balance the risks and benefits of immunizations for your child. * Recognize red flags that should raise alarms about vaccine- related information you read in the media. * Determine whether or not a vaccine is the cause of an adverse event or disease. * Find up-to-date, complete, and scientifically valid information about vaccines so you can make informed decisions about immunizations. "A detailed look at all the controversies swirling around vaccines. It should be required reading for parents who have vaccine concerns." Ari Brown, MD, FAAP, Pediatrician and author of Baby 411