Welcome to 97-hour weeks. Welcome to life and death decisions. Welcome to a constant tsunami of bodily fluids. Welcome to earning less than the hospital parking meter. Wave goodbye to your friends and relationships. Welcome to the life of a junior doctor. Scribbled in secret after endless days, sleepless nights and missed weekends, comedian and former junior doctor Adam Kay’s This Is Going to Hurt provides a no-holds-barred account of his time on the NHS front line (with a foreword attempting to explain the National Health Service to a non-UK audience). Hilarious, horrifying and heartbreaking by turns, this is everything you wanted to know—and more than a few things you didn't—about life on and off the hospital ward. And yes, it may leave a scar.

The latest groundbreaking tome from Tim Ferriss, the #1 New York Times best-selling author of The 4-Hour Workweek.From the author:“For the last two years, I’ve interviewed more than 200 world-class performers for my podcast, The Tim Ferriss Show. The guests range from super celebs (Jamie Foxx, Arnold Schwarzenegger, etc.) and athletes (icons of powerlifting, gymnastics, surfing, etc.) to legendary Special Operations commanders and black-market biochemists. For most of my guests, it’s the first time they’ve agreed to a two-to-three-hour interview. This unusual depth has helped make The Tim Ferriss Show the first business/interview podcast to pass 100 million downloads.“This book contains the distilled tools, tactics, and ‘inside baseball’ you won’t find anywhere else. It also includes new tips from past guests, and life lessons from new ‘guests’ you haven’t met.“What makes the show different is a relentless focus on actionable details. This is reflected in the questions. For example: What do these people do in the first sixty minutes of each morning? What do their workout routines look like, and why? What books have they gifted most to other people? What are the biggest wastes of time for novices in their field? What supplements do they take on a daily basis?“I don’t view myself as an interviewer. I view myself as an experimenter. If I can’t test something and replicate results in the messy reality of everyday life, I’m not interested.“Everything within these pages has been vetted, explored, and applied to my own life in some fashion. I’ve used dozens of the tactics and philosophies in high-stakes negotiations, high-risk environments, or large business dealings. The lessons have made me millions of dollars and saved me years of wasted effort and frustration.“I created this book, my ultimate notebook of high-leverage tools, for myself. It’s changed my life, and I hope the same for you.”

With an introduction by Will SelfA classic work of psychology, this international bestseller provides a groundbreaking insight into the human mind.In his most extraordinary book, Oliver Sacks recounts the stories of patients with inexplicable and often inescapable neurological disorders. Here are people who have lost their memories and with them their pasts; who can no longer recognize everyday objects or those they love; who suffer mental anguish and yet are gifted with uncanny artistic or mathematical talents. But while no two cases are alike, each one is treated with unparalleled compassion and wisdom.A fascinating exploration of the mysteries of the human mind, The Man Who Mistook His Wife for a Hat is a million-copy bestseller by the twentieth century's greatest neurologist.

Winner of the Pulitzer Prize • New York Times Bestseller • Over Two Million Copies Sold“One of the most significant projects embarked upon by any intellectual of our generation” (Gregg Easterbrook, New York Times), Guns, Germs, and Steel presents a groundbreaking, unified narrative of human history.Why did Eurasians conquer, displace, or decimate Native Americans, Australians, and Africans, instead of the reverse? In this “artful, informative, and delightful” (William H. McNeill, New York Review of Books) book, a classic of our time, evolutionary biologist Jared Diamond dismantles racist theories of human history by revealing the environmental factors actually responsible for its broadest patterns.The story begins 13,000 years ago, when Stone Age hunter-gatherers constituted the entire human population. Around that time, the developmental paths of human societies on different continents began to diverge greatly. Early domestication of wild plants and animals in the Fertile Crescent, China, Mesoamerica, the Andes, and other areas gave peoples of those regions a head start at a new way of life. But the localized origins of farming and herding proved to be only part of the explanation for their differing fates. The unequal rates at which food production spread from those initial centers were influenced by other features of climate and geography, including the disparate sizes, locations, and even shapes of the continents. Only societies that moved away from the hunter-gatherer stage went on to develop writing, technology, government, and organized religions as well as deadly germs and potent weapons of war. It was those societies, adventuring on sea and land, that invaded others, decimating native inhabitants through slaughter and the spread of disease.A major landmark in our understanding of human societies, Guns, Germs, and Steel chronicles the way in which the modern world, and its inequalities, came to be.

A New York Times bestseller/Washington Post Notable Book of 2017/NPR Best Books of 2017/Wall Street Journal Best Books of 2017"This book will serve as the definitive guide to the past and future of health care in America.”—Siddhartha Mukherjee, Pulitzer Prize-winning author of The Emperor of All Maladies and The GeneAt a moment of drastic political upheaval, An American Sickness is a shocking investigation into our dysfunctional healthcare system - and offers practical solutions to its myriad problems.In these troubled times, perhaps no institution has unraveled more quickly and more completely than American medicine. In only a few decades, the medical system has been overrun by organizations seeking to exploit for profit the trust that vulnerable and sick Americans place in their healthcare. Our politicians have proven themselves either unwilling or incapable of reining in the increasingly outrageous costs faced by patients, and market-based solutions only seem to funnel larger and larger sums of our money into the hands of corporations. Impossibly high insurance premiums and inexplicably large bills have become facts of life; fatalism has set in. Very quickly Americans have been made to accept paying more for less. How did things get so bad so fast?Breaking down this monolithic business into the individual industries—the hospitals, doctors, insurance companies, and drug manufacturers—that together constitute our healthcare system, Rosenthal exposes the recent evolution of American medicine as never before. How did healthcare, the caring endeavor, become healthcare, the highly profitable industry? Hospital systems, which are managed by business executives, behave like predatory lenders, hounding patients and seizing their homes. Research charities are in bed with big pharmaceutical companies, which surreptitiously profit from the donations made by working people. Patients receive bills in code, from entrepreneurial doctors they never even saw.The system is in tatters, but we can fight back. Dr. Elisabeth Rosenthal doesn't just explain the symptoms, she diagnoses and treats the disease itself. In clear and practical terms, she spells out exactly how to decode medical doublespeak, avoid the pitfalls of the pharmaceuticals racket, and get the care you and your family deserve. She takes you inside the doctor-patient relationship and to hospital C-suites, explaining step-by-step the workings of a system badly lacking transparency. This is about what we can do, as individual patients, both to navigate the maze that is American healthcare and also to demand far-reaching reform. An American Sickness is the frontline defense against a healthcare system that no longer has our well-being at heart.

A Best Book of 2021 by Bloomberg BusinessWeek, Time, and The Washington PostThe bestselling author of Leonardo da Vinci and Steve Jobs returns with a “compelling” (The Washington Post) account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his codiscovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is an “enthralling detective story” (Oprah Daily) that involves the most profound wonders of nature, from the origins of life to the future of our species.

While supervising a small group of interns at a major New York medical center, Dr. Robert Marion asked three of them to keep a careful diary over the course of a year. Andy, Mark, and Amy vividly describe their real-life lessons in treating very sick children; confronting child abuse and the awful human impact of the AIDS epidemic; skirting the indifference of the hospital bureaucracy; and overcoming their own fears, insecurities, and constant fatigue. Their stories are harrowing and often funny; their personal triumph is unforgettable.This updated edition of The Intern Blues includes a new preface from the author discussing the status of medical training in America today and a new afterword updating the reader on the lives of the three young interns who first shared their stories with readers more than a decade ago.

The dead do not hide the truth and they never lie. Through me the dead can speak ...Dr Richard Shepherd is the UK's foremost forensic pathologist, his job to understand the deaths which may have no natural cause. From crime scene to court room, his findings are crucial to the pursuit of justice. His work has seen killers put behind bars, exonerated the innocent, and turned open and shut cases on their heads.Shepherd's obsession with revealing the secrets of the dead is personal. At medical school, while performing his first autopsy, he held the heart of the patient in his hand and thought of his late mother, taken too early by heart disease.He became driven by the challenge of finding the truth, of seeing justice, and by compassion: sometimes for the dead, but always for those they have left behind.Thoughtful, revealing, chilling, sometimes bizarre and always unputdownable, Unnatural Causes is the true crime book of the year.

Full of heart and humor, a memoir about becoming a doctor that's unlike anything you've ever read before.All Tony Youn ever wanted was to fit in. One of two Asian‑American kids in a small midwestern town, he was tall and thin with Coke‑bottle glasses, Hannibal Lecter headgear, a bowl cut, and a protruding jaw that grew even faster than his comic‑book collection. He finally got his chance senior year as he lay strapped in an oral surgeon's chair having his jaw broken and reset--a brutal makeover that led him to his calling.Egged on by his overachieving Korean father ("Doctor never get fired."), Tony spent the next four years mired in the angst, flubs, triumphs, nonstop studying, intermittent heavy drinking, and sexual frustration of medical school. He entered a shy, skinny nerd with no nerve, no game, and no clue. He left a doctor.Heartwarming and laugh‑out‑loud funny, In Stitches is a universal coming‑of‑age story about a kid who found the best in himself by bringing out the best in others and finally learned to be comfortable in his own skin.

“Pollan keeps you turning the pages . . . cleareyed and assured.” —New York TimesA #1 New York Times Bestseller, New York Times Book Review 10 Best Books of 2018, and New York Times Notable BookA brilliant and brave investigation into the medical and scientific revolution taking place around psychedelic drugs--and the spellbinding story of his own life-changing psychedelic experiencesWhen Michael Pollan set out to research how LSD and psilocybin (the active ingredient in magic mushrooms) are being used to provide relief to people suffering from difficult-to-treat conditions such as depression, addiction and anxiety, he did not intend to write what is undoubtedly his most personal book. But upon discovering how these remarkable substances are improving the lives not only of the mentally ill but also of healthy people coming to grips with the challenges of everyday life, he decided to explore the landscape of the mind in the first person as well as the third. Thus began a singular adventure into various altered states of consciousness, along with a dive deep into both the latest brain science and the thriving underground community of psychedelic therapists. Pollan sifts the historical record to separate the truth about these mysterious drugs from the myths that have surrounded them since the 1960s, when a handful of psychedelic evangelists inadvertently catalyzed a powerful backlash against what was then a promising field of research.A unique and elegant blend of science, memoir, travel writing, history, and medicine, How to Change Your Mind is a triumph of participatory journalism. By turns dazzling and edifying, it is the gripping account of a journey to an exciting and unexpected new frontier in our understanding of the mind, the self, and our place in the world. The true subject of Pollan's "mental travelogue" is not just psychedelic drugs but also the eternal puzzle of human consciousness and how, in a world that offers us both suffering and joy, we can do our best to be fully present and find meaning in our lives.

What to Expect When You're Expecting meets Freakonomics: an award-winning economist disproves standard recommendations about pregnancy to empower women while they're expectingPregnancy—unquestionably one of the most profound, meaningful experiences of adulthood—can reduce otherwise intelligent women to, well, babies. We’re told to avoid cold cuts, sushi, alcohol, and coffee, but aren’t told why these are forbidden. Rules for prenatal testing are hard and fast—and unexplained. Are these recommendations even correct? Are all of them right for every mom-to-be? In Expecting Better, award-winning economist Emily Oster proves that pregnancy rules are often misguided and sometimes flat-out wrong.A mom-to-be herself, Oster debunks the myths of pregnancy using her particular mode of critical thinking: economics, the study of how we get what we want. Oster knows that the value of anything—a home, an amniocentesis—is in the eyes of the informed beholder, and like any complicated endeavor, pregnancy is not a one-size-fits-all affair. And yet medicine often treats it as such. Are doctors working from bad data? Are well-meaning friends and family perpetuating false myths and raising unfounded concerns? Oster’s answer is yes, and often.Pregnant women face an endless stream of decisions, from the casual (Can I eat this?) to the frightening (Is it worth risking a miscarriage to test for genetic defects?). Expecting Better presents the hard facts and real-world advice you’ll never get at the doctor’s office or in the existing literature. Oster’s revelatory work identifies everything from the real effects of caffeine and tobacco to the surprising dangers of gardening.Any expectant mother knows that the health of her baby is paramount, but she will be less anxious and better able to enjoy a healthy pregnancy if she is informed . . . and can have the occasional glass of wine.* * *Numbers are not subject to someone else’s interpretation—math doesn’t lie. Expectant economist Emily Oster set out to inform parents-to-be about the truth of pregnancy using the most up-to-date data so that they can make the best decisions for their pregnancies. The results she found were often very surprising…· It’s fine to have the occasional glass of wine – even one every day – in the second and third trimesters.· There is nothing to fear from sushi, but do stay away from raw milk cheese.· Sardines and herring are the fish of choice to give your child those few extra IQ points.· There is no evidence that bed rest is helpful in preventing or treating any complications of pregnancy.· Many unnecessary labor inductions could be avoided by simply staying hydrated.· Epidurals are great for pain relief and fine for your baby, but they do carry some risks for mom.· Limiting women to ice chips during labor is an antiquated practice; you should at least be able to sneak in some Gatorade.· You shouldn’t worry about dyeing your hair or cleaning the cat’s litter box, but gardening while pregnant can actually be risky.· Hot tubs, hot baths, hot yoga: avoid (at least during the first trimester).· You should be more worried about gaining too little weight during pregnancy than gaining too much.· Most exercise during pregnancy is fine (no rock climbing!), but there isn’t much evidence that it has benefits. Except for exercising your pelvic floor with Kegels: that you should be doing.· Your eggs do not have a 35-year-old sell-by date: plenty of women get pregnant after 35 and there is no sudden drop in fertility on your birthday.· Miscarriage risks from tests like the CVS and Amniocentesis are far lower than cited by most doctors.· Pregnancy nausea may be unpleasant, but it’s a good sign: women who are sick are less likely to miscarry.

A piercing and scientifically grounded look at the emergence of the coronavirus pandemic and how it will change the way we live—"excellent and timely." (The New Yorker)Apollo's Arrow offers a riveting account of the impact of the coronavirus pandemic as it swept through American society in 2020, and of how the recovery will unfold in the coming years. Drawing on momentous (yet dimly remembered) historical epidemics, contemporary analyses, and cutting-edge research from a range of scientific disciplines, bestselling author, physician, sociologist, and public health expert Nicholas A. Christakis explores what it means to live in a time of plague—an experience that is paradoxically uncommon to the vast majority of humans who are alive, yet deeply fundamental to our species.Unleashing new divisions in our society as well as opportunities for cooperation, this 21st-century pandemic has upended our lives in ways that will test, but not vanquish, our already frayed collective culture. Featuring new, provocative arguments and vivid examples ranging across medicine, history, sociology, epidemiology, data science, and genetics, Apollo's Arrow envisions what happens when the great force of a deadly germ meets the enduring reality of our evolved social nature.

#1 NEW YORK TIMES BESTSELLER • OPRAH’S BOOK CLUB PICK • ONE OF GQ's TOP 50 BOOKS OF LITERARY JOURNALISM IN THE 21st CENTURY • The heartrending story of a midcentury American family with twelve children, six of them diagnosed with schizophrenia, that became science's great hope in the quest to understand the disease."Reads like a medical detective journey and sheds light on a topic so many of us face: mental illness." —Oprah WinfreyDon and Mimi Galvin seemed to be living the American dream. After World War II, Don's work with the Air Force brought them to Colorado, where their twelve children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years, there was an established script for a family like the Galvins--aspiration, hard work, upward mobility, domestic harmony--and they worked hard to play their parts. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the ten Galvin boys, one after another, were diagnosed as schizophrenic. How could all this happen to one family?What took place inside the house on Hidden Valley Road was so extraordinary that the Galvins became one of the first families to be studied by the National Institute of Mental Health. Their story offers a shadow history of the science of schizophrenia, from the era of institutionalization, lobotomy, and the schizophrenogenic mother to the search for genetic markers for the disease, always amid profound disagreements about the nature of the illness itself. And unbeknownst to the Galvins, samples of their DNA informed decades of genetic research that continues today, offering paths to treatment, prediction, and even eradication of the disease for future generations.With clarity and compassion, bestselling and award-winning author Robert Kolker uncovers one family's unforgettable legacy of suffering, love, and hope.

The classic personal account of Watson and Crick’s groundbreaking discovery of the structure of DNA, now with an introduction by Sylvia Nasar, author of A Beautiful Mind.By identifying the structure of DNA, the molecule of life, Francis Crick and James Watson revolutionized biochemistry and won themselves a Nobel Prize. At the time, Watson was only twenty-four, a young scientist hungry to make his mark. His uncompromisingly honest account of the heady days of their thrilling sprint against other world-class researchers to solve one of science’s greatest mysteries gives a dazzlingly clear picture of a world of brilliant scientists with great gifts, very human ambitions, and bitter rivalries.With humility unspoiled by false modesty, Watson relates his and Crick’s desperate efforts to beat Linus Pauling to the Holy Grail of life sciences, the identification of the basic building block of life. Never has a scientist been so truthful in capturing in words the flavor of his work.

Your essential handbook to staying well in the modern world The immune system is your constant guardian, fighting around the clock to protect you from disease. There’s a lot you can do to strengthen this first line of defense against all kinds of threats, from COVID-19 to cancer. Now, immunologist Dr. Jenna Macciochi gives us a crash course on how the immune system actually works―and how to keep yours in shape―with authoritative guidance on:the best foods to eat to strengthen your immune system the importance of movement, and how often to exercise the essential link between immunity and sleep its surprising connection to your mental health.

'Endlessly fascinating and full of surprises. Easily one of my books of the year' BILL BRYSONThe myth-busting science behind our modern attitudes to exercise: what our bodies really need, why it matters, and its effects on health and wellbeing.In industrialized nations, our sedentary lifestyles have contributed to skyrocketing rates of obesity and diseases like diabetes. A key remedy, we are told, is exercise - voluntary physical activity for the sake of health. However, most of us struggle to stay fit, and our attitudes to exercise are plagued by misconceptions, finger-pointing and anxiety.But, as Daniel Lieberman shows in Exercised, the first book of its kind by a leading scientific expert, we never evolved to exercise. We are hardwired for moderate exertion throughout each day, not triathlons or treadmills. Drawing on over a decade of high-level scientific research and eye-opening insights from evolutionary biology and anthropology, Lieberman explains precisely how exercise can promote health; debunks persistent myths about sitting, speed, strength and endurance; and points the way towards more enjoyable and physically active living in the modern world.'Myth-busting, illuminating, brilliant - Lieberman will completely change the way you think about your body' Professor ALICE ROBERTS, presenter of Our Incredible Human Journey

WINNER OF THE 2020 PULITZER PRIZE IN GENERAL NONFICTION"The Undying is a startling, urgent intervention in our discourses about sickness and health, art and science, language and literature, and mortality and death. In dissecting what she terms 'the ideological regime of cancer,' Anne Boyer has produced a profound and unforgettable document on the experience of life itself." ―Sally Rooney, author of Normal People"Anne Boyer’s radically unsentimental account of cancer and the 'carcinogenosphere' obliterates cliche. By demonstrating how her utterly specific experience is also irreducibly social, she opens up new spaces for thinking and feeling together. The Undying is an outraged, beautiful, and brilliant work of embodied critique." ―Ben Lerner, author of The Topeka SchoolA week after her forty-first birthday, the acclaimed poet Anne Boyer was diagnosed with highly aggressive triple-negative breast cancer. For a single mother living paycheck to paycheck who had always been the caregiver rather than the one needing care, the catastrophic illness was both a crisis and an initiation into new ideas about mortality and the gendered politics of illness.A twenty-first-century Illness as Metaphor, as well as a harrowing memoir of survival, The Undying explores the experience of illness as mediated by digital screens, weaving in ancient Roman dream diarists, cancer hoaxers and fetishists, cancer vloggers, corporate lies, John Donne, pro-pain ”dolorists,” the ecological costs of chemotherapy, and the many little murders of capitalism. It excoriates the pharmaceutical industry and the bland hypocrisies of ”pink ribbon culture” while also diving into the long literary line of women writing about their own illnesses and ongoing deaths: Audre Lorde, Kathy Acker, Susan Sontag, and others.A genre-bending memoir in the tradition of The Argonauts, The Undying will break your heart, make you angry enough to spit, and show you contemporary America as a thing both desperately ill and occasionally, perversely glorious.Includes black-and-white illustrations