From the Los Angeles Times Book Prize–winning historian, the colorful, dramatic story of Charles Darwin’s journey on HMS Beagle that inspired the evolutionary theories in his path-breaking books On the Origin of Species and The Descent of ManWhen twenty-two-year-old aspiring geologist Charles Darwin boarded HMS Beagle in 1831 with his microscopes and specimen bottles—invited by ship’s captain Robert FitzRoy who wanted a travel companion at least as much as a ship’s naturalist—he hardly thought he was embarking on what would become perhaps the most important and epoch-changing voyage in scientific history. Nonetheless, over the course of the five-year journey around the globe in often hard and hazardous conditions, Darwin would make observations and gather samples that would form the basis of his revolutionary theories about the origin of species and natural selection.Drawing on a rich range of revealing letters, diary entries, recollections of those who encountered him, and Darwin’s and FitzRoy’s own accounts of what transpired, Diana Preston chronicles the epic voyage as it unfolded, tracing Darwin’s growth from untested young man to accomplished adventurer and natural scientist in his own right. Darwin often left the ship to climb mountains, navigate rivers, or ride hundreds of miles, accompanied by local guides whose languages he barely understood, across pampas and through rainforests in search of further unique specimens. From the wilds of Patagonia to the Galápagos and other Atlantic and Pacific islands, as Preston vibrantly relates, Darwin collected and contrasted volcanic rocks and fossils large and small, witnessed an earthquake, and encountered the Argentinian rhea, Falklands fox, and Galápagos finch, through which he began to discern connections between deep past and present.Darwin never left Britain again after his return in 1836, though his mind journeyed far and wide to develop the theories that were first revealed, after great delay and with trepidation about their reception, in 1859 with the publication of his epochal book On the Origin of Species. Offering a unique portrait of one of history’s most consequential figures, The Evolution of Charles Darwin is a vital contribution to our understanding of life on Earth.

Welcome to 97-hour weeks. Welcome to life and death decisions. Welcome to a constant tsunami of bodily fluids. Welcome to earning less than the hospital parking meter. Wave goodbye to your friends and relationships. Welcome to the life of a junior doctor. Scribbled in secret after endless days, sleepless nights and missed weekends, comedian and former junior doctor Adam Kay’s This Is Going to Hurt provides a no-holds-barred account of his time on the NHS front line (with a foreword attempting to explain the National Health Service to a non-UK audience). Hilarious, horrifying and heartbreaking by turns, this is everything you wanted to know—and more than a few things you didn't—about life on and off the hospital ward. And yes, it may leave a scar.

Thoroughly revised for its Fifth Edition, this concise textbook is ideal for medical students in internal medicine clinical clerkships. This edition's content reflects current guidelines from the Clerkship Directors in Internal Medicine and the National Board of Medical Examiners on topics necessary for this rotation. The book is a collaboration between clinical faculty at the Medical College of Wisconsin and clerkship students who have reviewed all chapters for relevance to the clerkship experience. A companion Website will offer the fully searchable text; 39 additional chapters; 300 multiple-choice questions with detailed explanations, organized to mimic end-of-rotation exam settings; ECG and CXR images with explanations; narrated physical examination videos; and "Medicine Rounds," a quick review of questions frequently asked on rounds. The online chapters include:\n\nCongenital Heart Diseases Electrocardiography Pulmonary Function Testing Cystic Fibrosis Pulmonary Hypertension Adult Respiratory Distress Syndrome (ARDS) Mycoses Thyroid Cancer Benign and Malignant Liver Tumors Nonalcoholic Fatty Liver Disease Pancreatic Cancer Leukopenia Reactive Leukocytosis Eosinophilia Blood Transfusion Heparin Induced Thrombocytopenia Renal Tubular Acidosis Acid-based Abnormalities Somatization Substance Abuse and Dependence General Approach to Dermatologic Disorders Dermatitis and Eczema Vitiligo Herpes (HSV and HZV) Common Warts Eryspipelas Scabies Anaphylaxis Drug Allergy Chronic Pain Red Eye Benign Breast Problems Preconception Care and Issues in Pregnancy Functional Decline in the Elderly\n

Tony Buzan is the inventor of Mind Maps and The Mind Map Book is the original and best book on how to use them effectively in your own life.Often referred to as â~the Swiss army knife for the brainâ(tm), Mind Maps are a ground-breaking, note-taking technique that have already revolutionised the lives of many millions of people around the world and taken the educational and business world by storm.This practical full-colour book will transform the way you plan and organise your life. At school theyâ(tm)re perfect for taking notes, revising for exams and planning essays; at work theyâ(tm)re great for improving your organisational skills, preparing and running meetings and planning strategy; and in your personal life, no matter what youâ(tm)re trying  to plan, be it a wedding, a garden or even your own future â" Mind Maps can help.Discover how Mind Maps can boost your memory, unlock your creativity, improve your concentration, revolutionise how you think and learn.Discover today how Mind Maps can change your life.

A Washington Post Notable Work of NonfictionA Telegraph Book of the YearA sweeping history of American psychiatry―from the mental hospital to the brain lab―that reveals the devastating treatments doctors have inflicted on their patients (especially women) in the name of science and questions our massive reliance on meds.For more than two hundred years, disturbances of the mind―the sorts of things that were once called “madness”―have been studied and treated by the medical profession. Mental illness, some insist, is a disease like any other, whose origins can be identified and from which one can be cured. But is this true?In this masterful account of America’s quest to understand and treat everything from anxiety to psychosis, one of the most provocative thinkers writing about psychiatry today sheds light on its tumultuous past. Desperate Remedies brings together a galaxy of mind doctors working in and out of institutional settings: psychologists and psychoanalysts, neuroscientists, and cognitive behavioral therapists, social reformers and advocates of mental hygiene, as well as patients and their families desperate for relief.Andrew Scull begins with the birth of the asylum in the reformist zeal of the 1830s and carries us through to the latest drug trials and genetic studies. He carefully reconstructs the rise and fall of state-run mental hospitals to explain why so many of the mentally ill are now on the street and why so many of those whose bodies were experimented on were women. In his compelling closing chapters, he reveals how drug companies expanded their reach to treat a growing catalog of ills, leading to an epidemic of over-prescribing while deliberately concealing debilitating side effects.Carefully researched and compulsively readable, Desperate Remedies is a definitive account of America’s long battle with mental illness that challenges us to rethink our deepest assumptions about who we are and how we think and feel.

From the New York Times bestselling author of The Black Swan, a bold new work that challenges many of our long-held beliefs about risk and reward, politics and religion, finance and personal responsibilityIn his most provocative and practical book yet, one of the foremost thinkers of our time redefines what it means to understand the world, succeed in a profession, contribute to a fair and just society, detect nonsense, and influence others. Citing examples ranging from Hammurabi to Seneca, Antaeus the Giant to Donald Trump, Nassim Nicholas Taleb shows how the willingness to accept one’s own risks is an essential attribute of heroes, saints, and flourishing people in all walks of life.As always both accessible and iconoclastic, Taleb challenges long-held beliefs about the values of those who spearhead military interventions, make financial investments, and propagate religious faiths. Among his insights:For social justice, focus on symmetry and risk sharing. You cannot make profits and transfer the risks to others, as bankers and large corporations do. You cannot get rich without owning your own risk and paying for your own losses. Forcing skin in the game corrects this asymmetry better than thousands of laws and regulations.Ethical rules aren’t universal. You’re part of a group larger than you, but it’s still smaller than humanity in general.Minorities, not majorities, run the world. The world is not run by consensus but by stubborn minorities imposing their tastes and ethics on others.You can be an intellectual yet still be an idiot. “Educated philistines” have been wrong on everything from Stalinism to Iraq to low-carb diets.Beware of complicated solutions (that someone was paid to find). A simple barbell can build muscle better than expensive new machines.True religion is commitment, not just faith. How much you believe in something is manifested only by what you’re willing to risk for it.The phrase “skin in the game” is one we have often heard but rarely stopped to truly dissect. It is the backbone of risk management, but it’s also an astonishingly rich worldview that, as Taleb shows in this book, applies to all aspects of our lives. As Taleb says, “The symmetry of skin in the game is a simple rule that’s necessary for fairness and justice, and the ultimate BS-buster,” and “Never trust anyone who doesn’t have skin in the game. Without it, fools and crooks will benefit, and their mistakes will never come back to haunt them.”

Here's all the help you need to survive your internal medicine clerkship! This handy guide offers you practical, must-have guidance on the causes, clinical evaluation, and treatment of common medical conditions―knowledge that every student can and should master. Section 1 outlines the practical skills and procedures you must know on rotation; Sections 2 and 3 describe health conditions organized by presentation (symptom, sign, abnormal lab value) and by specific diagnosis, allowing you to approach a given health problem from either direction.\n\nOrganizes material according to the types of questions that you will typically ask during the clerkship. \nUses Learning Objectives and Key Points boxes to make complex data easier to remember. \nProvides Cases to illustrate the types of clinical scenarios you may experience. Includes a multiple-choice exam at the end of the book to help you prepare for clinical exams.\n\n\nOffers updates throughout to incorporate the latest knowledge and practices in internal medicine. \nProvides complete rationales for all of the answers in the practice exam for increased learning. \nFeatures a new easier-to-read design with a better organization for more efficient study.\n

Step-Up to Medicine is your lifeline for the clinical years of medical school. This book was originally written by third-year medical students searching for the perfect review book—not finding it on the market, they wrote it themselves! Now in its third edition, Step-Up to Medicine boils down the full scope of tested pathology in a single ingenious tool. Each element is tailored for immediate content absorption, and an all-new, full-color interior differentiate elements for even faster, more efficient review. And, Step-Up to Medicine, third edition provides two types of self-assessment—the kinds of questions you will ask yourself as a clinician plus USMLE-style practice questions. This review book gives you just the Step-Up to the medicine clerkship, accompanying shelf exams, and USMLE Step 2 that you need! NEW Features for this blockbuster edition:\nFull-color, updated interior design brings the content to you in a rousing, memorable style. Full-color, updated art program illustrates concepts when a picture says it best—plenty of clinical images also supplement topics. New content on evidence-based medicine keeps you current and informed to guide your clinical decision making. Expanded content on drug dosing is added where relevant. \n CLASSIC Features students swear by:\nComplete coverage of high-yield medical topics ensures you are test ready Clinical Pearls boxes help you “file away” clinical medicine connections for handy retrieval at test time Quick Hits glimmering in the margins highlight highly testable material—just see how the sparks fly at test time\n BONUS Material and study resources:\neBook with the fully searchable text is available via thePoint . NEW 300 USMLE-style questions provide another means of self-assessment and practice for those exams NEW Audio clips of breath and heart sounds also available on thePoint\n

With an introduction by Will SelfA classic work of psychology, this international bestseller provides a groundbreaking insight into the human mind.In his most extraordinary book, Oliver Sacks recounts the stories of patients with inexplicable and often inescapable neurological disorders. Here are people who have lost their memories and with them their pasts; who can no longer recognize everyday objects or those they love; who suffer mental anguish and yet are gifted with uncanny artistic or mathematical talents. But while no two cases are alike, each one is treated with unparalleled compassion and wisdom.A fascinating exploration of the mysteries of the human mind, The Man Who Mistook His Wife for a Hat is a million-copy bestseller by the twentieth century's greatest neurologist.

From the Preface.....In the following pages I have confined myself in the main to those problems of philosophy in regard to which I thought it possible to say something positive and constructive, since merely negative criticism seemed out of place. For this reason, theory of knowledge occupies a larger space than metaphysics in the present volume, and some topics much discussed by philosophers are treated very briefly, if at all. I have derived valuable assistance from unpublished writings of G. E. Moore and J. M. Keynes: from the former, as regards the relations of sense-data to physical objects, and from the latter as regards probability and induction. I have also profited greatly by the criticisms and suggestions of Professor Gilbert Murray. 1912

**LONGLISTED FOR THE 2023 PEN/JOHN KENNETH GALBRAITH AWARD FOR NONFICTION****LONGLISTED FOR THE 2023 ANDREW CARNEGIE MEDALS FOR EXCELLENCE****WINNER OF THE 2022 POZ AWARD FOR BEST IN LITERATURE**"An irresistibly readable and humane exploration of the barbarities of class...readers are gifted that most precious of things in these muddled times: a clear lens through which to see the world."―Naomi Klein, New York Times bestselling author of This Changes Everything and The Shock DoctrineFrom preeminent LGBTQ scholar, social critic, and journalist Steven W. Thrasher comes a powerful and crucial exploration of one of the most pressing issues of our times: how viruses expose the fault lines of society.Having spent a ground-breaking career studying the racialization, policing, and criminalization of HIV, Dr. Thrasher has come to understand a deeper truth at the heart of our society: that there are vast inequalities in who is able to survive viruses and that the ways in which viruses spread, kill, and take their toll are much more dependent on social structures than they are on biology alone.Told through the heart-rending stories of friends, activists, and teachers navigating the novel coronavirus, HIV, and other viruses, Dr. Thrasher brings the reader with him as he delves into the viral underclass and lays bare its inner workings. In the tradition of Isabel Wilkerson’s Caste and Michelle Alexander’s The New Jim Crow, The Viral Underclass helps us understand the world more deeply by showing the fraught relationship between privilege and survival.

A Best Book of 2021 by Bloomberg BusinessWeek, Time, and The Washington PostThe bestselling author of Leonardo da Vinci and Steve Jobs returns with a “compelling” (The Washington Post) account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his codiscovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is an “enthralling detective story” (Oprah Daily) that involves the most profound wonders of nature, from the origins of life to the future of our species.

Enrich your learning and reinforce key concepts with the companion volume to Internal Medicine Essentials for Clerkship Students 2! Newly reorganized and fully updated, MKSAP for Students 4 is designed to help medical students succeed in their clerkship rotation. This new edition offers 450 new patient-centered self-assessment questions and answers, which help define and assess mastery of the core knowledge base requisite to internal medicine education in medical school. Questions are designed to simulate the end of rotation and USMLE question format. Each question is aligned with content in Internal Medicine Essentials for Clerkship Students 2, and is followed by critiques and new key points. MKSAP for Students 4 has over 450 all new questions, answers, and critiques, 23 new Electrocardiogram questions, and 35 new color figure dermatology questions. MSKAP for Students 4 helps you master the knowledge you are expected to know by the end of your clerkship. The accompanying CD-ROM automatically tracks progress, assesses areas for further focus, includes a topical index, random question ordering, and integrated access to an online medical dictionary and multimedia library.

A New York Times BestsellerFinalist for the 2022 Kirkus Prize | Named a best book of the year by The Guardian"Enthralling. Harrowing. Heartbreaking. And utterly redemptive. Lindsey Fitzharris hit this one out of the park." ―Erik Larson, author of The Splendid and the VileLindsey Fitzharris, the award-winning author of The Butchering Art, presents the compelling, true story of a visionary surgeon who rebuilt the faces of the First World War’s injured heroes, and in the process ushered in the modern era of plastic surgery.From the moment the first machine gun rang out over the Western Front, one thing was clear: humankind’s military technology had wildly surpassed its medical capabilities. Bodies were battered, gouged, hacked, and gassed. The First World War claimed millions of lives and left millions more wounded and disfigured. In the midst of this brutality, however, there were also those who strove to alleviate suffering. The Facemaker tells the extraordinary story of such an individual: the pioneering plastic surgeon Harold Gillies, who dedicated himself to reconstructing the burned and broken faces of the injured soldiers under his care.Gillies, a Cambridge-educated New Zealander, became interested in the nascent field of plastic surgery after encountering the human wreckage on the front. Returning to Britain, he established one of the world’s first hospitals dedicated entirely to facial reconstruction. There, Gillies assembled a unique group of practitioners whose task was to rebuild what had been torn apart, to re-create what had been destroyed. At a time when losing a limb made a soldier a hero, but losing a face made him a monster to a society largely intolerant of disfigurement, Gillies restored not just the faces of the wounded but also their spirits.The Facemaker places Gillies’s ingenious surgical innovations alongside the dramatic stories of soldiers whose lives were wrecked and repaired. The result is a vivid account of how medicine can be an art, and of what courage and imagination can accomplish in the presence of relentless horror.

While supervising a small group of interns at a major New York medical center, Dr. Robert Marion asked three of them to keep a careful diary over the course of a year. Andy, Mark, and Amy vividly describe their real-life lessons in treating very sick children; confronting child abuse and the awful human impact of the AIDS epidemic; skirting the indifference of the hospital bureaucracy; and overcoming their own fears, insecurities, and constant fatigue. Their stories are harrowing and often funny; their personal triumph is unforgettable.This updated edition of The Intern Blues includes a new preface from the author discussing the status of medical training in America today and a new afterword updating the reader on the lives of the three young interns who first shared their stories with readers more than a decade ago.

BRAND NEW, Exactly same ISBN as listed, Please double check ISBN carefully before ordering.

Like its best-selling predecessor, the fifth edition of this popular series contains over 450 multiple-choice questions, updated references, color photographs and ECG tracings. MKSAP for Students is intended for third-year students participating in their required internal medicine clerkship and for fourth-year students on an advanced medicine clerkship. All questions are formatted as clinical vignettes that resemble the types of questions students encounter on the examination at the end of the clerkship and on the USMLE licensing examination. Each question has a detailed answer critique that identifies the correct answer, an explanation of why that answer is correct and the other options are incorrect, an educational objective and a short bibliography. Succinct Key Points summarize the important take home messages for each question. MKSAP for Students 5 is supported by its companion textbook, Internal Medicine Essentials for Students All questions in MKSAP for Students are associated with relevant content in the Essentials textbook that can directly answer the question.

Winner of the 2023 PROSE Award for Excellence in Biological and Life Sciences and the 2023 Chautauqua Prize!Named a New York Times Notable Book and a Best Book of the Year by The Economist, Oprah Daily, BookPage, Book Riot, the New York Public Library, and more!In The Song of the Cell, the extraordinary author of the Pulitzer Prize–winning The Emperor of All Maladies and the #1 New York Times bestseller The Gene “blends cutting-edge research, impeccable scholarship, intrepid reporting, and gorgeous prose into an encyclopedic study that reads like a literary page-turner” (Oprah Daily).Mukherjee begins this magnificent story in the late 1600s, when a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth-merchant, Antonie van Leeuwenhoek looked down their handmade microscopes. What they saw introduced a radical concept that swept through biology and medicine, touching virtually every aspect of the two sciences, and altering both forever. It was the fact that complex living organisms are assemblages of tiny, self-contained, self-regulating units. Our organs, our physiology, our selves—hearts, blood, brains—are built from these compartments. Hooke christened them “cells.”The discovery of cells—and the reframing of the human body as a cellular ecosystem—announced the birth of a new kind of medicine based on the therapeutic manipulations of cells. A hip fracture, a cardiac arrest, Alzheimer’s dementia, AIDS, pneumonia, lung cancer, kidney failure, arthritis, COVID pneumonia—all could be reconceived as the results of cells, or systems of cells, functioning abnormally. And all could be perceived as loci of cellular therapies.Filled with writing so vivid, lucid, and suspenseful that complex science becomes thrilling, The Song of the Cell tells the story of how scientists discovered cells, began to understand them, and are now using that knowledge to create new humans. Told in six parts, and laced with Mukherjee’s own experience as a researcher, a doctor, and a prolific reader, The Song of the Cell is both panoramic and intimate—a masterpiece on what it means to be human.“In an account both lyrical and capacious, Mukherjee takes us through an evolution of human understanding: from the seventeenth-century discovery that humans are made up of cells to our cutting-edge technologies for manipulating and deploying cells for therapeutic purposes” (The New Yorker).

The dead do not hide the truth and they never lie. Through me the dead can speak ...Dr Richard Shepherd is the UK's foremost forensic pathologist, his job to understand the deaths which may have no natural cause. From crime scene to court room, his findings are crucial to the pursuit of justice. His work has seen killers put behind bars, exonerated the innocent, and turned open and shut cases on their heads.Shepherd's obsession with revealing the secrets of the dead is personal. At medical school, while performing his first autopsy, he held the heart of the patient in his hand and thought of his late mother, taken too early by heart disease.He became driven by the challenge of finding the truth, of seeing justice, and by compassion: sometimes for the dead, but always for those they have left behind.Thoughtful, revealing, chilling, sometimes bizarre and always unputdownable, Unnatural Causes is the true crime book of the year.

Full of heart and humor, a memoir about becoming a doctor that's unlike anything you've ever read before.All Tony Youn ever wanted was to fit in. One of two Asian‑American kids in a small midwestern town, he was tall and thin with Coke‑bottle glasses, Hannibal Lecter headgear, a bowl cut, and a protruding jaw that grew even faster than his comic‑book collection. He finally got his chance senior year as he lay strapped in an oral surgeon's chair having his jaw broken and reset--a brutal makeover that led him to his calling.Egged on by his overachieving Korean father ("Doctor never get fired."), Tony spent the next four years mired in the angst, flubs, triumphs, nonstop studying, intermittent heavy drinking, and sexual frustration of medical school. He entered a shy, skinny nerd with no nerve, no game, and no clue. He left a doctor.Heartwarming and laugh‑out‑loud funny, In Stitches is a universal coming‑of‑age story about a kid who found the best in himself by bringing out the best in others and finally learned to be comfortable in his own skin.

Portable and extremely practical, On Call Principles and Protocols, 5th Edition, by Drs. Marshall and Ruedy, is the bestselling handbook you can trust to guide you quickly and confidently through virtually any on-call situation. This new edition takes you step by step through the most common on-call problems and approaches, giving you up-to-date information and clear protocols on what to do and how to do it quickly, from phone calls to "elevator thoughts" to patients’ bedsides. You’ll gain speed, skill, and knowledge with every call - from diagnosing a difficult or life-threatening situation to prescribing the right medication.\n\nEffectively manage calls in the hospital with coverage of topics such as Approach to Diagnosis and Management of On-Call Problems; Documentation; Assessment and Management of Volume Status; and AIDS, HBV, HCV, Influenza, and the House Officer. Access key information on the most common on-call problems and approaches with consistent, templated coverage of what to do from the initial phone call, "Elevator Thoughts," how to immediately identify major threats to life, and what to do at the bedside. Learn the questions you should ask to assess the urgency of each situation, and master the ideal approach to diagnose and manage patients, communicate with colleagues and families, and avoid common mistakes for every call. Understand the major threats to life you must consider before arriving at bedside. Find information quickly with an easy-to-read format, color highlighting of medications and other critical information, and a unique layout designed for fast reference. Keep this portable guide right where you need it - in your pocket when you’re on call. \n\nConfidently assess and manage common on-call problems with comprehensive updates throughout this edition. Learn how best to handle life-threatening issues regarding stroke in a brand-new chapter. Quickly access a detailed, updated and expanded formulary of commonly used medications. \nBe prepared when on call with quick and concise answers to common clinical issues

National Book Award finalist Breathless tells the story of the worldwide scientific race to decipher the coronavirus SARS-CoV-2, trace its source, and make possible the vaccines to fight the Covid-19 pandemic—a “luminous, passionate account of the defining crisis of our time.” (The New York Times).Breathless is a “gripping” (The Atlantic) but “clear-eyed analysis” (Time) of SARs-CoV-2 and its fierce journey through the human population, as seen by the scientists who study its origin, its ever-changing nature, and its capacity to kill us. David Quammen expertly shows how strange new viruses emerge from animals into humans as we disrupt wild ecosystems and how those viruses adapt to their human hosts, sometimes causing global catastrophe. He explains why this coronavirus will probably be a “forever virus,” destined to circulate among humans and bedevil us endlessly, in one variant form or another. As scientists labor to catch it, comprehend it, and control it, with their high-tech tools and methods, the virus finds ways of escape.Based on interviews with nearly one hundred scientists, including leading virologists in China and around the world, Quammen explains that:-Infectious disease experts saw this pandemic coming-Some scientists, for more than two decades, warned that “the next big one” would be caused by a changeable new virus—very possibly a coronavirus—but such warnings were ignored for political or economic reasons-The precise origins of this virus may not be known for years, but some clues are compelling, and some suppositions can be dismissed-And much moreWritten by “one of our finest explainers of the natural world for decades” (Chicago Tribune), This “compelling and terrifying” (The New York Times) account is an unparalleled look inside the frantic international race to understand and control SARS-CoV-2—and what it might mean for the next potential global health crisis.

A NEW YORK TIMES BESTSELLERFINALIST FOR THE 2022 NATIONAL BOOK AWARD FOR NONFICTIONNamed one of the BEST BOOKS OF 2022 by NPR, The New Yorker, Time, and Vogue“Remarkable.” –Andrew Solomon, The New York Times Book Review"At once a rigorous work of scholarship and a radical act of empathy.”—Esquire"A ray of light into those isolated cocoons of darkness that, at one time or another, may afflict us all.” —The Wall Street Journal"Essential."—The Boston GlobeA landmark exploration of one of the most consequential and mysterious issues of our time: the rise of chronic illness and autoimmune diseasesA silent epidemic of chronic illnesses afflicts tens of millions of Americans: these are diseases that are poorly understood, frequently marginalized, and can go undiagnosed and unrecognized altogether. Renowned writer Meghan O’Rourke delivers a revelatory investigation into this elusive category of “invisible” illness that encompasses autoimmune diseases, post-treatment Lyme disease syndrome, and now long COVID, synthesizing the personal and the universal to help all of us through this new frontier.Drawing on her own medical experiences as well as a decade of interviews with doctors, patients, researchers, and public health experts, O’Rourke traces the history of Western definitions of illness, and reveals how inherited ideas of cause, diagnosis, and treatment have led us to ignore a host of hard-to-understand medical conditions, ones that resist easy description or simple cures. And as America faces this health crisis of extraordinary proportions, the populations most likely to be neglected by our institutions include women, the working class, and people of color.Blending lyricism and erudition, candor and empathy, O’Rourke brings together her deep and disparate talents and roles as critic, journalist, poet, teacher, and patient, synthesizing the personal and universal into one monumental project arguing for a seismic shift in our approach to disease. The Invisible Kingdom offers hope for the sick, solace and insight for their loved ones, and a radical new understanding of our bodies and our health.

Now in paperback: a #1 New York Times–bestselling author’s gripping chronicle of “two doctors . . . bringing light to those in darkness” (Time) Second Suns is the unforgettable true story of two very different doctors with a common mission: to rid the world of preventable blindness. Dr. Geoffrey Tabin was the high-achieving “bad boy” of his class at Harvard Medical School. Dr. Sanduk Ruit grew up in a remote village in the Himalayas, where cataract blindness―easily curable in modern hospitals―amounts to an epidemic. Together, they pioneered a new surgical method, by which they have restored sight to over 100,000 people―all for about $20 per operation.Master storyteller David Oliver Relin brings the doctors’ work to vivid life through poignant portraits of their patients, from old men who can once again walk treacherous mountain trails, to children who can finally see their mothers’ faces. The Himalayan Cataract Project is changing the world―one pair of eyes at a time. 16-page B&W photo insert

A Kirkus Best Science and Medicine Book of 2022Longlisted for the PEN/E.O. Wilson Literary Science Writing Award“Every new book by Frans de Waal is a cause for excitement, and this one is no different. A breath of fresh air in the cramped debate about the differences between men and women. Fascinating, nuanced, and very timely.” ―Rutger Bregman, author of Humankind: A Hopeful HistoryIn Different, world-renowned primatologist Frans de Waal draws on decades of observation and studies of both human and animal behavior to argue that despite the linkage between gender and biological sex, biology does not automatically support the traditional gender roles in human societies. While humans and other primates do share some behavioral differences, biology offers no justification for existing gender inequalities.Using chimpanzees and bonobos to illustrate this point―two ape relatives that are genetically equally close to humans―de Waal challenges widely held beliefs about masculinity and femininity, and common assumptions about authority, leadership, cooperation, competition, filial bonds, and sexual behavior. Chimpanzees are male-dominated and violent, while bonobos are female-dominated and peaceful. In both species, political power needs to be distinguished from physical dominance. Power is not limited to the males, and both sexes show true leadership capacities.Different is a fresh and thought-provoking approach to the long-running debate about the balance between nature and nurture, and where sex and gender roles fit in. De Waal peppers his discussion with details from his own life―a Dutch childhood in a family of six boys, his marriage to a French woman with a different orientation toward gender, and decades of academic turf wars over outdated scientific theories that have proven hard to dislodge from public discourse. He discusses sexual orientation, gender identity, and the limitations of the gender binary, exceptions to which are also found in other primates.With humor, clarity, and compassion, Different seeks to broaden the conversation about human gender dynamics by promoting an inclusive model that embraces differences, rather than negating them. 12 pages of illustrations; 24 drawings

Gynaecologists Catherine and Reg Hamlin left Australia in 1959 on a short contract to establish a midwifery school in Ethiopia. Over 40 years later, Catherine is still there, running one of the most outstanding medical programmes in the world. The Hamlins dedicated their lives to women suffering the catastrophic effects of obstructed labour. The awful injuries that such labour produces are called fistulae, and until the Hamlins began their work in Ethiopia, fistula sufferers were neglected and forgotten - a vast group of women facing a lifetime of incapacity and degradation. Catherine and Reg, with their team of dedicated fistula surgeons, have successfully operated on over 25,000 women, and the Addis Ababa Fistula Hospital, the hospital they opened in 1974, has become a major teaching institution for gynaecologists from all over Ethiopia and the developing world. Since Reg's death, Catherine and her team have continued the work.

New York Times bestsellerOne of the top ten books of the year at The New York Times Book Review, TheWall Street Journal, Vulture/New York magazineA best book of the year at Los Angeles Times, Time, NPR, The Washington Post, Bookforum, The New Yorker, Vogue, KirkusThe acclaimed, award-winning New Yorker writer Rachel Aviv offers a groundbreaking exploration of mental illness and the mind, and illuminates the startling connections between diagnosis and identity.Strangers to Ourselves poses fundamental questions about how we understand ourselves in periods of crisis and distress. Drawing on deep, original reporting as well as unpublished journals and memoirs, Rachel Aviv writes about people who have come up against the limits of psychiatric explanations for who they are. She follows an Indian woman celebrated as a saint who lives in healing temples in Kerala; an incarcerated mother vying for her children’s forgiveness after recovering from psychosis; a man who devotes his life to seeking revenge upon his psychoanalysts; and an affluent young woman who, after a decade of defining herself through her diagnosis, decides to go off her meds because she doesn’t know who she is without them. Animated by a profound sense of empathy, Aviv’s gripping exploration is refracted through her own account of living in a hospital ward at the age of six and meeting a fellow patient with whom her life runs parallel―until it no longer does.Aviv asks how the stories we tell about mental disorders shape their course in our lives―and our identities, too. Challenging the way we understand and talk about illness, her account is a testament to the porousness and resilience of the mind.

You can go after the job you want...and get it! You can take the job you have...and improve it! You can take any situation you're in...and make it work for you!Since its release in 1936, How to Win Friends and Influence People has sold more than 15 million copies. Dale Carnegie's first book is a timeless bestseller, packed with rock-solid advice that has carried thousands of now famous people up the ladder of success in their business and personal lives.As relevant as ever before, Dale Carnegie's principles endure, and will help you achieve your maximum potential in the complex and competitive modern age.Learn the six ways to make people like you, the twelve ways to win people to your way of thinking, and the nine ways to change people without arousing resentment.

At the age of thirty-six, on the verge of completing a decade’s training as a neurosurgeon, Paul Kalanithi was diagnosed with inoperable lung cancer. One day he was a doctor treating the dying, the next he was a patient struggling to live.When Breath Becomes Air chronicles Kalanithi’s transformation from a medical student asking what makes a virtuous and meaningful life into a neurosurgeon working in the core of human identity – the brain – and finally into a patient and a new father.

Washington Post • 10 Best Graphic Novels of 2022A vibrant and informative debut with “great documentary power” (Alison Bechdel), Fine is an elegantly illustrated celebration of the transgender community. As graphic artist Rhea Ewing neared college graduation in 2012, they became consumed by the question: What is gender? This obsession sparked a quest in which they eagerly approached both friends and strangers in their quiet Midwest town for interviews to turn into comics. A decade later, this project exploded into a sweeping portrait of the intricacies of gender expression with interviewees from all over the country. Questions such as “How do you Identify” produced fiercely honest stories of dealing with adolescence, taking hormones, changing pronouns―and how these experiences can differ, often drastically, depending on culture, race, and religion. Amidst beautifully rendered scenes emerges Ewing’s own story of growing up in rural Kentucky, grappling with their identity as a teenager, and ultimately finding themself through art―and by creating something this very fine. Tender and wise, inclusive and inviting, Fine is an indispensable account for anyone eager to define gender in their own terms. Two color throughout

What to Expect When You're Expecting meets Freakonomics: an award-winning economist disproves standard recommendations about pregnancy to empower women while they're expectingPregnancy—unquestionably one of the most profound, meaningful experiences of adulthood—can reduce otherwise intelligent women to, well, babies. We’re told to avoid cold cuts, sushi, alcohol, and coffee, but aren’t told why these are forbidden. Rules for prenatal testing are hard and fast—and unexplained. Are these recommendations even correct? Are all of them right for every mom-to-be? In Expecting Better, award-winning economist Emily Oster proves that pregnancy rules are often misguided and sometimes flat-out wrong.A mom-to-be herself, Oster debunks the myths of pregnancy using her particular mode of critical thinking: economics, the study of how we get what we want. Oster knows that the value of anything—a home, an amniocentesis—is in the eyes of the informed beholder, and like any complicated endeavor, pregnancy is not a one-size-fits-all affair. And yet medicine often treats it as such. Are doctors working from bad data? Are well-meaning friends and family perpetuating false myths and raising unfounded concerns? Oster’s answer is yes, and often.Pregnant women face an endless stream of decisions, from the casual (Can I eat this?) to the frightening (Is it worth risking a miscarriage to test for genetic defects?). Expecting Better presents the hard facts and real-world advice you’ll never get at the doctor’s office or in the existing literature. Oster’s revelatory work identifies everything from the real effects of caffeine and tobacco to the surprising dangers of gardening.Any expectant mother knows that the health of her baby is paramount, but she will be less anxious and better able to enjoy a healthy pregnancy if she is informed . . . and can have the occasional glass of wine.* * *Numbers are not subject to someone else’s interpretation—math doesn’t lie. Expectant economist Emily Oster set out to inform parents-to-be about the truth of pregnancy using the most up-to-date data so that they can make the best decisions for their pregnancies. The results she found were often very surprising…· It’s fine to have the occasional glass of wine – even one every day – in the second and third trimesters.· There is nothing to fear from sushi, but do stay away from raw milk cheese.· Sardines and herring are the fish of choice to give your child those few extra IQ points.· There is no evidence that bed rest is helpful in preventing or treating any complications of pregnancy.· Many unnecessary labor inductions could be avoided by simply staying hydrated.· Epidurals are great for pain relief and fine for your baby, but they do carry some risks for mom.· Limiting women to ice chips during labor is an antiquated practice; you should at least be able to sneak in some Gatorade.· You shouldn’t worry about dyeing your hair or cleaning the cat’s litter box, but gardening while pregnant can actually be risky.· Hot tubs, hot baths, hot yoga: avoid (at least during the first trimester).· You should be more worried about gaining too little weight during pregnancy than gaining too much.· Most exercise during pregnancy is fine (no rock climbing!), but there isn’t much evidence that it has benefits. Except for exercising your pelvic floor with Kegels: that you should be doing.· Your eggs do not have a 35-year-old sell-by date: plenty of women get pregnant after 35 and there is no sudden drop in fertility on your birthday.· Miscarriage risks from tests like the CVS and Amniocentesis are far lower than cited by most doctors.· Pregnancy nausea may be unpleasant, but it’s a good sign: women who are sick are less likely to miscarry.

In the highly anticipated Thinking, Fast and Slow, Kahneman takes us on a groundbreaking tour of the mind and explains the two systems that drive the way we think. System 1 is fast, intuitive, and emotional; System 2 is slower, more deliberative, and more logical. Kahneman exposes the extraordinary capabilities—and also the faults and biases—of fast thinking, and reveals the pervasive influence of intuitive impressions on our thoughts and behavior. The impact of loss aversion and overconfidence on corporate strategies, the difficulties of predicting what will make us happy in the future, the challenges of properly framing risks at work and at home, the profound effect of cognitive biases on everything from playing the stock market to planning the next vacation—each of these can be understood only by knowing how the two systems work together to shape our judgments and decisions.Engaging the reader in a lively conversation about how we think, Kahneman reveals where we can and cannot trust our intuitions and how we can tap into the benefits of slow thinking. He offers practical and enlightening insights into how choices are made in both our business and our personal lives—and how we can use different techniques to guard against the mental glitches that often get us into trouble. Thinking, Fast and Slow will transform the way you think about thinking.

Her name was Henrietta Lacks, but scientists know her as HeLa. Born a poor black tobacco farmer, her cancer cells - taken without her knowledge - became a multimillion-dollar industry and one of the most important tools in medicine. Yet Henrietta's family did not learn of her 'immortality' until more than twenty years after her death, with devastating consequences ...Balancing the beauty and drama of scientific discovery with dark questions about who owns the stuff our bodies are made of, "The Immortal Life of Henrietta Lacks" is an extraordinary journey in search of the soul and story of a real woman, whose cells live on today in all four corners of the world. "A fascinating, harrowing, necessary book". (Hilary Mantel, "Guardian"). "A heartbreaking account of racism and injustice". ("Metro"). "A fine book...a gripping read...The book has deservedly been a huge bestseller in the US. It should be here, too". ("Sunday Times").

This psychology title explains how, by altering our perspective, we can achieve happiness, dispel disharmony and enter a state of perfect equilibrium - a state of flow.

A piercing and scientifically grounded look at the emergence of the coronavirus pandemic and how it will change the way we live—"excellent and timely." (The New Yorker)Apollo's Arrow offers a riveting account of the impact of the coronavirus pandemic as it swept through American society in 2020, and of how the recovery will unfold in the coming years. Drawing on momentous (yet dimly remembered) historical epidemics, contemporary analyses, and cutting-edge research from a range of scientific disciplines, bestselling author, physician, sociologist, and public health expert Nicholas A. Christakis explores what it means to live in a time of plague—an experience that is paradoxically uncommon to the vast majority of humans who are alive, yet deeply fundamental to our species.Unleashing new divisions in our society as well as opportunities for cooperation, this 21st-century pandemic has upended our lives in ways that will test, but not vanquish, our already frayed collective culture. Featuring new, provocative arguments and vivid examples ranging across medicine, history, sociology, epidemiology, data science, and genetics, Apollo's Arrow envisions what happens when the great force of a deadly germ meets the enduring reality of our evolved social nature.

Sir William Osler (1849–1919) had a long and distinguished career as a physician and professor at McGill University, the University of Pennsylvania, the Johns Hopkins University, and finally, as the Regius Chair in Medicine at Oxford University. Over the course of his professional life, Osler gave many addresses—mostly to medical students—on medical ethics, medicine and the humanities, the relationship between the medical practitioner and the patient, and, as the titular essay makes clear, on the “way of life” he advocated for the ethical physician. He remains an inspiration to many contemporary medical practitioners; there are active Osler Societies throughout the world.While Osler’s talks were frequently published during his lifetime and they have been published individually and in different compilations since his death, none contain the over 1500 annotations that appear here, notes that serve to explain the many philosophical, biblical, historical, and literary allusions contained in Osler’s writings.This thoroughly explicated selection of Sir William Osler’s writings will be cherished by physicians, medical students, nurses, philosophers, theologians, and ethicists in this—and future—generations.

#1 NEW YORK TIMES BESTSELLER • OPRAH’S BOOK CLUB PICK • ONE OF GQ's TOP 50 BOOKS OF LITERARY JOURNALISM IN THE 21st CENTURY • The heartrending story of a midcentury American family with twelve children, six of them diagnosed with schizophrenia, that became science's great hope in the quest to understand the disease."Reads like a medical detective journey and sheds light on a topic so many of us face: mental illness." —Oprah WinfreyDon and Mimi Galvin seemed to be living the American dream. After World War II, Don's work with the Air Force brought them to Colorado, where their twelve children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years, there was an established script for a family like the Galvins--aspiration, hard work, upward mobility, domestic harmony--and they worked hard to play their parts. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the ten Galvin boys, one after another, were diagnosed as schizophrenic. How could all this happen to one family?What took place inside the house on Hidden Valley Road was so extraordinary that the Galvins became one of the first families to be studied by the National Institute of Mental Health. Their story offers a shadow history of the science of schizophrenia, from the era of institutionalization, lobotomy, and the schizophrenogenic mother to the search for genetic markers for the disease, always amid profound disagreements about the nature of the illness itself. And unbeknownst to the Galvins, samples of their DNA informed decades of genetic research that continues today, offering paths to treatment, prediction, and even eradication of the disease for future generations.With clarity and compassion, bestselling and award-winning author Robert Kolker uncovers one family's unforgettable legacy of suffering, love, and hope.

The classic personal account of Watson and Crick’s groundbreaking discovery of the structure of DNA, now with an introduction by Sylvia Nasar, author of A Beautiful Mind.By identifying the structure of DNA, the molecule of life, Francis Crick and James Watson revolutionized biochemistry and won themselves a Nobel Prize. At the time, Watson was only twenty-four, a young scientist hungry to make his mark. His uncompromisingly honest account of the heady days of their thrilling sprint against other world-class researchers to solve one of science’s greatest mysteries gives a dazzlingly clear picture of a world of brilliant scientists with great gifts, very human ambitions, and bitter rivalries.With humility unspoiled by false modesty, Watson relates his and Crick’s desperate efforts to beat Linus Pauling to the Holy Grail of life sciences, the identification of the basic building block of life. Never has a scientist been so truthful in capturing in words the flavor of his work.

Your essential handbook to staying well in the modern world The immune system is your constant guardian, fighting around the clock to protect you from disease. There’s a lot you can do to strengthen this first line of defense against all kinds of threats, from COVID-19 to cancer. Now, immunologist Dr. Jenna Macciochi gives us a crash course on how the immune system actually works―and how to keep yours in shape―with authoritative guidance on:the best foods to eat to strengthen your immune system the importance of movement, and how often to exercise the essential link between immunity and sleep its surprising connection to your mental health.

'Endlessly fascinating and full of surprises. Easily one of my books of the year' BILL BRYSONThe myth-busting science behind our modern attitudes to exercise: what our bodies really need, why it matters, and its effects on health and wellbeing.In industrialized nations, our sedentary lifestyles have contributed to skyrocketing rates of obesity and diseases like diabetes. A key remedy, we are told, is exercise - voluntary physical activity for the sake of health. However, most of us struggle to stay fit, and our attitudes to exercise are plagued by misconceptions, finger-pointing and anxiety.But, as Daniel Lieberman shows in Exercised, the first book of its kind by a leading scientific expert, we never evolved to exercise. We are hardwired for moderate exertion throughout each day, not triathlons or treadmills. Drawing on over a decade of high-level scientific research and eye-opening insights from evolutionary biology and anthropology, Lieberman explains precisely how exercise can promote health; debunks persistent myths about sitting, speed, strength and endurance; and points the way towards more enjoyable and physically active living in the modern world.'Myth-busting, illuminating, brilliant - Lieberman will completely change the way you think about your body' Professor ALICE ROBERTS, presenter of Our Incredible Human Journey

WINNER OF THE 2020 PULITZER PRIZE IN GENERAL NONFICTION"The Undying is a startling, urgent intervention in our discourses about sickness and health, art and science, language and literature, and mortality and death. In dissecting what she terms 'the ideological regime of cancer,' Anne Boyer has produced a profound and unforgettable document on the experience of life itself." ―Sally Rooney, author of Normal People"Anne Boyer’s radically unsentimental account of cancer and the 'carcinogenosphere' obliterates cliche. By demonstrating how her utterly specific experience is also irreducibly social, she opens up new spaces for thinking and feeling together. The Undying is an outraged, beautiful, and brilliant work of embodied critique." ―Ben Lerner, author of The Topeka SchoolA week after her forty-first birthday, the acclaimed poet Anne Boyer was diagnosed with highly aggressive triple-negative breast cancer. For a single mother living paycheck to paycheck who had always been the caregiver rather than the one needing care, the catastrophic illness was both a crisis and an initiation into new ideas about mortality and the gendered politics of illness.A twenty-first-century Illness as Metaphor, as well as a harrowing memoir of survival, The Undying explores the experience of illness as mediated by digital screens, weaving in ancient Roman dream diarists, cancer hoaxers and fetishists, cancer vloggers, corporate lies, John Donne, pro-pain ”dolorists,” the ecological costs of chemotherapy, and the many little murders of capitalism. It excoriates the pharmaceutical industry and the bland hypocrisies of ”pink ribbon culture” while also diving into the long literary line of women writing about their own illnesses and ongoing deaths: Audre Lorde, Kathy Acker, Susan Sontag, and others.A genre-bending memoir in the tradition of The Argonauts, The Undying will break your heart, make you angry enough to spit, and show you contemporary America as a thing both desperately ill and occasionally, perversely glorious.Includes black-and-white illustrations